Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer.
Cell Biochem Biophys
; 72(3): 657-60, 2015 Jul.
Article
em En
| MEDLINE
| ID: mdl-27352184
ABSTRACT
Gastric cancer has high morbidity and mortality. Identification of patients with high gastric cancer risk at early stage will improve patient prognosis. In this study, we examined two single nucleotide polymorphism (SNP) sites of COX-2 gene in gastric cancer patients and explored the effect of the SNPs on the morbidity of gastric cancer. We found that the SNPs COX-2-1195G/A and COX-2-8473T/C are correlated with the occurrence of gastric cancer, and the patients with variants A and C of the SNPs are liable to have gastric cancer. Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Polimorfismo de Nucleotídeo Único
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Ciclo-Oxigenase 2
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article