Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species.
J Infect Dis
; 214(suppl 3): S297-S302, 2016 10 15.
Article
em En
| MEDLINE
| ID: mdl-27354372
ABSTRACT
Filoviruses are strongly associated with several species of bats as their natural reservoirs. In this study, we determined the replication potential of all filovirus species Marburg marburgvirus, Taï Forest ebolavirus, Reston ebolavirus, Sudan ebolavirus, Zaire ebolavirus, and Bundibugyo ebolavirus. Filovirus replication was supported by all cell lines derived from 6 Old and New World bat species the hammer-headed fruit bat, Buettikofer's epauletted fruit bat, the Egyptian fruit bat, the Jamaican fruit bat, the Mexican free-tailed bat and the big brown bat. In addition, we showed that Marburg virus Angola and Ebola virus Makona-WPGC07 efficiently replicated at 37°C, 37°-41°C, or 41°C, contrary to the hypothesis that temporal elevation in temperature due to flight affects filovirus replication in bats.
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Base de dados:
MEDLINE
Assunto principal:
Reservatórios de Doenças
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Quirópteros
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Filoviridae
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Infecções por Filoviridae
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Doença pelo Vírus Ebola
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Doença do Vírus de Marburg
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article