Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1.

Troutman, Scott; Moleirinho, Susana; Kota, Smitha; Nettles, Kendall; Fallahi, Mohammad; Johnson, Gary L; Kissil, Joseph L

Troutman, Scott; Moleirinho, Susana; Kota, Smitha; Nettles, Kendall; Fallahi, Mohammad; Johnson, Gary L; Kissil, Joseph L.

Afiliação

Troutman S; Department of Cancer Biology, The Scripps Institute, Jupiter, FL, 33458, USA.
Moleirinho S; Department of Cancer Biology, The Scripps Institute, Jupiter, FL, 33458, USA.
Kota S; Department of Cancer Biology, The Scripps Institute, Jupiter, FL, 33458, USA.
Nettles K; Department of Cancer Biology, The Scripps Institute, Jupiter, FL, 33458, USA.
Fallahi M; Department of Informatics Core, The Scripps Institute, Jupiter, FL, 33458, USA.
Johnson GL; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kissil JL; Department of Cancer Biology, The Scripps Institute, Jupiter, FL, 33458, USA.

Oncotarget ; 7(34): 54515-54525, 2016 Aug 23.

Article em En | MEDLINE | ID: mdl-27363027

Assuntos

Quinase 1 de Adesão Focal/antagonistas & inibidores; Neurilemoma/tratamento farmacológico; Neurofibromina 2/fisiologia; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/farmacologia; Piridinas/farmacologia; Animais; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Crizotinibe; Humanos; Camundongos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

FAK; NF2; crizotinib; neurofibromatosis; signal transduction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Neurofibromina 2 / Inibidores de Proteínas Quinases / Quinase 1 de Adesão Focal / Neurilemoma Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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