Clostridium difficile infection epidemiology and management: Comparison of results of a prospective study with a retrospective one in a reference teaching and research hospital in Northern Italy.
Am J Infect Control
; 44(11): 1214-1218, 2016 11 01.
Article
em En
| MEDLINE
| ID: mdl-27372227
ABSTRACT
BACKGROUND:
Clostridium difficile-associated disease (CDAD) is the most common infectious antibiotic-associated diarrhea and is a growing health care problem. Prevention of Clostridium difficile infection focuses on clinical and epidemiologic infection control measures.METHODS:
Between 2008 and 2009, we conducted a retrospective study that showed an incidence of CDAD among the highest reported in the literature. Subsequently, we developed a preventive protocol that was adopted in our hospital in 2010. We then conducted a prospective study to investigate prevalence, incidence, and mortality of CDAD and to compare the results with those of the retrospective study, evaluating adherence to preventive measures and their efficacy.RESULTS:
In both studies, prevalence and incidence significantly increased in older patients. Crude prevalence was similar in the 2 studies. The incidence rate increased by 36%, with a significant increase only in the C and D wards. In-hospital mortality rose in both prevalent and incident cases. Regarding adhesion to hospital protocol, 77% of prevalent cases were treated with the required procedure. The highest percentage of isolated patients was achieved in C and D wards. In these wards we detected lower training hours per nurse. However, in 2013, we observed a significant decrease in incidence of CDAD and found a hospital prevalence of 0.33%.CONCLUSIONS:
Health care personnel education could be more important than the possibility of isolating infected patients in single rooms.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
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Controle de Infecções
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Infecções por Clostridium
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Educação Médica
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article