Identification of 1,4-thiomorpholine-3-carboxylic acid (TMA) in normal human urine.
FEBS Lett
; 250(1): 75-7, 1989 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-2737303
ABSTRACT
The sulfur-containing cyclic imino acid 1,4-thiomorpholine-3-carboxylic acid (TMA) has been identified in normal human urine. After the enrichment procedure with ion-exchange chromatography, the urine extracts were reacted with diazomethane. Gas-liquid chromatography revealed the presence of two peaks with the same retention times exhibited by authentic TMA after the same derivatization. The two compounds have been identified by mass-spectrometry as the monomethylated and dimethylated derivatives of TMA. This result represents the first indication of the occurrence of TMA in a mammalian sample.
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Base de dados:
MEDLINE
Assunto principal:
Morfolinas
/
Iminoácidos
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article