Iriomoteolides-10a and 12a, Cytotoxic Macrolides from Marine Dinoflagellate Amphidinium Species.
Chem Pharm Bull (Tokyo)
; 64(7): 1019-23, 2016.
Article
em En
| MEDLINE
| ID: mdl-27373665
ABSTRACT
Two new macrolides, iriomoteolides-10a (1) and -12a (2), have been isolated from a marine dinoflagellate Amphidinium sp. (KCA09053 strain), and their structures were elucidated on the basis of a detailed two dimensional (2D)-NMR analysis. Compound 1 is a novel 21-membered Amphidinium macrolide, which contains one tetrahydrofuran ring, two ketone carbonyls, two hydroxyl groups, and six one-carbon branches. Compound 2 is a new 12-membered macrolide related to amphidinolide Q. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa and murine hepatocellular carcinoma MH134 cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dinoflagellida
/
Macrolídeos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article