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Inhibition of skin inflammation by baicalin ultradeformable vesicles.
Mir-Palomo, Silvia; Nácher, Amparo; Díez-Sales, Octavio; Ofelia Vila Busó, M A; Caddeo, Carla; Manca, Maria Letizia; Manconi, Maria; Fadda, Anna Maria; Saurí, Amparo Ruiz.
Afiliação
  • Mir-Palomo S; Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Spain. Electronic address: silmirpa@gmail.com.
  • Nácher A; Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Spain; Institute of Molecular Recognition and Technological Development, Inter-Universitary Institute from Polytechnic University of Valencia and University of Valencia, Spain.
  • Díez-Sales O; Dept. Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Spain; Institute of Molecular Recognition and Technological Development, Inter-Universitary Institute from Polytechnic University of Valencia and University of Valencia, Spain.
  • Ofelia Vila Busó MA; Dept. Physics and Chemistry, Faculty of Pharmacy, University of Valencia, Spain.
  • Caddeo C; Dept. Farmaco Chimico Tecnologico, University of Cagliari, Cagliari 09124, Italy.
  • Manca ML; Dept. Farmaco Chimico Tecnologico, University of Cagliari, Cagliari 09124, Italy.
  • Manconi M; Dept. Farmaco Chimico Tecnologico, University of Cagliari, Cagliari 09124, Italy.
  • Fadda AM; Dept. Farmaco Chimico Tecnologico, University of Cagliari, Cagliari 09124, Italy.
  • Saurí AR; Dept. of Pathology, University of Valencia, Avda Blasco Ibañez 17, 46010 Valencia, Spain.
Int J Pharm ; 511(1): 23-29, 2016 Sep 10.
Article em En | MEDLINE | ID: mdl-27374324
The topical efficacy of baicalin, a natural flavonoid isolated from Scutellaria baicalensis Georgi, which has several beneficial properties, such as antioxidative, antiviral, anti-inflammatory and antiproliferative, is hindered by its poor aqueous solubility and low skin permeability. Therefore, its incorporation into appropriate phospholipid vesicles could be a useful tool to improve its local activity. To this purpose, baicalin at increasing concentrations up to saturation, was incorporated in ultradeformable vesicles, which were small in size (∼67nm), monodispersed (PI<0.19) and biocompatible, regardless of the concentration of baicalin, as confirmed by in vitro studies using fibroblasts. On the other hand, transdermal flux through human epidermis was concentration dependent. The in vivo results showed the significant anti-inflammatory activity of baicalin loaded nanovesicles irrespective of the concentration used, as they were able to reduce the skin damage induced by the phorbol ester (TPA) application, even in comparison with dexamethasone, a synthetic drug with anti-inflammatory properties. Overall results indicate that ultradeformable vesicles are promising nanosystems for the improvement of cutaneous delivery of baicalin in the treatment of skin inflammation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Absorção Cutânea / Flavonoides / Dermatite Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Absorção Cutânea / Flavonoides / Dermatite Idioma: En Ano de publicação: 2016 Tipo de documento: Article