Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice.

Kuno, Takuya; Hirayama-Kurogi, Mio; Ito, Shingo; Ohtsuki, Sumio

Kuno, Takuya; Hirayama-Kurogi, Mio; Ito, Shingo; Ohtsuki, Sumio.

Afiliação

Kuno T; Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Hirayama-Kurogi M; Department of Drug Metabolism and Pharmacokinetics, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd. , 463-10 Kagasuno, Kawauchi-cho, Tokushima, Tokushima 771-0192, Japan.
Ito S; Department of Pharmaceutical Microbiology, Graduate School of Pharmaceutical Sciences, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Ohtsuki S; Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University , 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

Mol Pharm ; 13(8): 2691-701, 2016 08 01.

Article em En | MEDLINE | ID: mdl-27376980

Assuntos

Microbioma Gastrointestinal/efeitos dos fármacos; Rim/metabolismo; Fígado/metabolismo; Animais; Antibacterianos; Masculino; Camundongos; Proteômica; Organismos Livres de Patógenos Específicos

Palavras-chave

antibiotics; drug-metabolizing enzyme; intestinal flora; quantitative proteomics; targeted proteomics; transporter

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Rim / Fígado Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbioma Gastrointestinal / Rim / Fígado Idioma: En Ano de publicação: 2016 Tipo de documento: Article