The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers.
Int J Neuropsychopharmacol
; 20(4): 346-350, 2017 04 01.
Article
em En
| MEDLINE
| ID: mdl-27401180
ABSTRACT
Background:
Healthy people with a family history of alcohol problems show a pattern of subjective responses to alcohol that resemble those of affected probands. Studies on ketamine suggest that up-regulation of N-methyl-D-aspartate receptors (NMDARs) underlies these effects, and point to a pharmacologically-responsive endophenotype reflecting enhanced risk for alcohol-use disorders.Methods:
Subjective stimulant and sedative effects were assessed before and during nitrous oxide (N2O; 50%) inhalation in heavy drinkers who were otherwise healthy.Results:
Participants with an ostensible family history of alcohol-use disorders (n = 23) were distinguishable from those without such familial risk (n = 37) by an enhanced stimulation-to-sedation ratio during N2O inhalation.Conclusion:
The pattern of subjective effects of N2O according to familial risk is remarkably similar to that previously seen with ketamine, supporting the idea of a common, NMDAR-mediated mechanism of action. N2O may prove to be a safe and accessible alternative to ketamine for probing heritable NMDAR dysregulation in neuropsychiatric disorders.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Consumo de Bebidas Alcoólicas
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Analgésicos não Narcóticos
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Endofenótipos
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Óxido Nitroso
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article