Anti-kidney antibody teratogenesis: evidence for a direct action on the rat conceptus by a mechanism involving the yolk sac.
Toxicol Lett
; 47(2): 197-203, 1989 May.
Article
em En
| MEDLINE
| ID: mdl-2741181
ABSTRACT
IgG from anti-rat kidney antiserum (anti-K) was added to 48-h cultures of 9.5-day whole rat conceptuses. At concentrations of 25 micrograms/ml and above, dysmorphogenesis of embryos (optic vesicle defects) was observed. Significant embryonic growth retardation was apparent at 75 micrograms/ml and above. Other abnormalities (neural tube defects, deficits in axial rotation, reduced somite numbers) were seen at 100 and 150 micrograms/ml. In separate experiments, anti-K inhibited pinocytosis of 125I-polyvinylpyrrolidone by isolated yolk sacs. All of these effects of anti-K are similar to those produced by anti-visceral yolk sac antiserum suggesting a similar mechanism of teratogenic action, namely interference with yolk-sac-mediated embryotrophic nutrition.
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Base de dados:
MEDLINE
Assunto principal:
Teratogênicos
/
Saco Vitelino
/
Anormalidades Múltiplas
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Embrião de Mamíferos
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Soros Imunes
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Rim
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article