Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization.

ABSTRACT

Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; xin yí qing fèi tang), a formula of traditional Japanese kampo medicine ( rì ben hàn yi) and traditional Chinese medicine (TCM; zhong yi), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization.