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Rufloxacin (MF-934): in vitro and in vivo antibacterial activity.
Ravizzola, G; Pinsi, G; Pirali, F; Colombrita, D; Foresti, I; Peroni, L; Turano, A.
Afiliação
  • Ravizzola G; Institute of Microbiology, University of Brescia, Italy.
Drugs Exp Clin Res ; 15(1): 11-5, 1989.
Article em En | MEDLINE | ID: mdl-2743869
ABSTRACT
Rufloxacin (MF-934) is a new quinolone which shows in vitro antibacterial activity against E. coli, Salmonella, Klebsiella, Proteus and Staphylococcus spp. Lower in vitro activity was observed with Pseudomonas, Serratia, Enterobacter and the streptococci group D. The antimicrobial activity of MF-934 in vitro is higher than that of nalidixic acid but lower than that of ciprofloxacin, ofloxacin, pefloxacin or norfloxacin. The protective effects of MF-934 in systemic infections in mice are lower than those of ciprofloxacin and ofloxacin. In respiratory infections in rats and in subcutaneous infections in guinea-pigs, the protective effects of MF-934 are of the same order as ciprofloxacin and ofloxacin. This is probably due to the pharmacokinetic properties of MF-934, i.e. the long half-life and tissue concentrations higher than plasma levels.
Assuntos
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Base de dados: MEDLINE Assunto principal: Bactérias / Quinolonas / Fluoroquinolonas / Anti-Infecciosos Idioma: En Ano de publicação: 1989 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Bactérias / Quinolonas / Fluoroquinolonas / Anti-Infecciosos Idioma: En Ano de publicação: 1989 Tipo de documento: Article