Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy.
Ther Deliv
; 7(8): 521-44, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27444493
ABSTRACT
AIM:
Parvifloron D is a natural diterpene with a broad and not selective cytotoxicity toward human tumor cells. In order to develop a targeted antimelanoma drug delivery platform for Parvifloron D, hybrid nanoparticles were prepared with biopolymers and functionalized with α-melanocyte stimulating hormone. Results/methodology:
Nanoparticles were produced according to a solvent displacement method and the physicochemical properties were assessed. It was shown that Parvifloron D is cytotoxic and can induce, both as free and as encapsulated drug, cell death in melanoma cells (human A375 and mouse B16V5). Parvifloron D-loaded nanoparticles showed a high encapsulation efficiency (87%) and a sustained release profile. In vitro experiments showed the nanoparticles' uptake and cell internalization.CONCLUSION:
Hybrid nanoparticles appear to be a promising platform for long-term drug release, presenting the desired structure and a robust performance for targeted anticancer therapy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Abietanos
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Nanopartículas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article