The oligodendrocyte-specific antibody 'CC1' binds Quaking 7.
J Neurochem
; 139(2): 181-186, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27454326
ABSTRACT
The mouse monoclonal antibody marketed as anti-adenomatous polyposis coli clone CC1, often referred to as CC1, is the antibody most commonly used to specifically label mature oligodendrocytes without labeling myelin. Previous studies have shown that despite being raised against adenomatous polyposis coli, this antibody binds another unknown antigen. We show that the CC1 antibody binds Quaking 7, an RNA-binding protein that is highly up-regulated in myelinating oligodendrocytes in the central nervous system. The monoclonal antibody anti-adenomatous polyposis coli (APC) clone CC1, is the antibody most commonly used to specifically label the cell bodies of mature oligodendrocytes. Despite being raised against APC, previous studies showed this antibody binds another unknown antigen. We show that the CC1 antibody binds Quaking (QKI) 7, an RNA-binding protein which is highly up-regulated in myelinating oligodendrocytes.
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Base de dados:
MEDLINE
Assunto principal:
Oligodendroglia
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Proteínas de Ligação a RNA
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Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article