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Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes.
Goldman, Jennifer L; Koen, Yakov M; Rogers, Steven A; Li, Kelin; Leeder, James S; Hanzlik, Robert P.
Afiliação
  • Goldman JL; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
  • Koen YM; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
  • Rogers SA; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
  • Li K; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
  • Leeder JS; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
  • Hanzlik RP; Divisions of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Hospital, University of Missouri, Kansas City, Missouri (J.L.G., J.S.L.); Department of Medicinal Chemistry, University of Kansas School of Pharmacy, Lawrence, Kansas (Y.M.K., R.P.H.); Baker & McKenzie L
Drug Metab Dispos ; 44(10): 1603-7, 2016 10.
Article em En | MEDLINE | ID: mdl-27457783
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trimetoprima / Microssomos Hepáticos / Proteínas / Anti-Infecciosos Urinários Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trimetoprima / Microssomos Hepáticos / Proteínas / Anti-Infecciosos Urinários Idioma: En Ano de publicação: 2016 Tipo de documento: Article