Your browser doesn't support javascript.
loading
Maternal HIV infection influences the microbiome of HIV-uninfected infants.
Bender, Jeffrey M; Li, Fan; Martelly, Shoria; Byrt, Erin; Rouzier, Vanessa; Leo, Marguerite; Tobin, Nicole; Pannaraj, Pia S; Adisetiyo, Helty; Rollie, Adrienne; Santiskulvong, Chintda; Wang, Shaun; Autran, Chloe; Bode, Lars; Fitzgerald, Daniel; Kuhn, Louise; Aldrovandi, Grace M.
Afiliação
  • Bender JM; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
  • Li F; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Martelly S; GHESKIO Centers, The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Ouest 15727, Haiti.
  • Byrt E; Departments of Epidemiology and Biostatistics, Columbia University, New York, NY 10032, USA. Center for Global Health, Weill-Cornell Medical College, New York, NY 10065, USA.
  • Rouzier V; GHESKIO Centers, The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Ouest 15727, Haiti.
  • Leo M; GHESKIO Centers, The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince, Ouest 15727, Haiti.
  • Tobin N; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Pannaraj PS; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
  • Adisetiyo H; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Rollie A; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Santiskulvong C; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
  • Wang S; Departments of Epidemiology and Biostatistics, Columbia University, New York, NY 10032, USA.
  • Autran C; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Bode L; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Fitzgerald D; Center for Global Health, Weill-Cornell Medical College, New York, NY 10065, USA.
  • Kuhn L; Departments of Epidemiology and Biostatistics, Columbia University, New York, NY 10032, USA.
  • Aldrovandi GM; Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA. gracea@mac.com.
Sci Transl Med ; 8(349): 349ra100, 2016 07 27.
Article em En | MEDLINE | ID: mdl-27464748
ABSTRACT
More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Microbiota Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por HIV / Microbiota Idioma: En Ano de publicação: 2016 Tipo de documento: Article