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History of multiple sclerosis in 2 successive pregnancies: A French and Italian cohort.
Benoit, Amandine; Durand-Dubief, Françoise; Amato, Maria-Pia; Portaccio, Emilio; Casey, Romain; Roggerone, Stéphanie; Androdias, Géraldine; Gignoux, Laurence; Ionescu, Iuliana; Marrosu, Maria-Giovanna; Cocco, Eleonora; Ghezzi, Angelo; Annovazzi, Pietro; Trojano, Maria; Simone, Marta; Marignier, Romain; Confavreux, Christian; Vukusic, Sandra.
Afiliação
  • Benoit A; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Durand-Dubief F; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Amato MP; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Portaccio E; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Casey R; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Roggerone S; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Androdias G; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Gignoux L; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Ionescu I; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Marrosu MG; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Cocco E; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Ghezzi A; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Annovazzi P; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Trojano M; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Simone M; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Marignier R; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Confavreux C; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
  • Vukusic S; From the Service de Neurologie A (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon/Bron; Centre des Neurosciences de Lyon (A.B., F.D.-D., S.R., G.A., L.G., I.I., R.M., C.C., S.V.), INSERM 1028 et CNRS UMR5292, Equipe Neur
Neurology ; 87(13): 1360-7, 2016 Sep 27.
Article em En | MEDLINE | ID: mdl-27466470
ABSTRACT

OBJECTIVE:

To evaluate the risk of relapses during pregnancy and in the first 3 months after delivery in 2 successive pregnancies in a cohort of French and Italian women with multiple sclerosis (MS).

METHODS:

A total of 93 women were included if they had had 2 pregnancies followed prospectively after MS onset between January 1993 and 2013. The association of a relapse during pregnancy or the first postpartum trimester in pregnancy 1 and pregnancy 2 was evaluated by univariate logistic regression.

RESULTS:

A majority of women did not experience any exacerbation in the 3 months after delivery (31.2% and 23.7%, respectively, relapsed after pregnancy 1 and 2; p = 0.32). A total of 7.6% had a relapse after both pregnancies. The risk of relapse after pregnancy 2 was not associated with the number of relapses in the prepregnancy year (odds ratio [OR] 1.52 [0.57-4.05]) or during pregnancy (OR 1.57 [0.52-4.79]) or with the occurrence of a relapse after pregnancy 1 (OR 0.86 [0.29-2.50]).

CONCLUSIONS:

Our work provides original data on the evolution of successive pregnancies in MS, showing a similar (and even lower) disease activity in the second pregnancy. There was no correlation of activity in successive pregnancies. Therefore, counseling of women with MS who consider having a second baby should be the same as for the first one.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Esclerose Múltipla Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Esclerose Múltipla Idioma: En Ano de publicação: 2016 Tipo de documento: Article