C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.

Lai, Weiyan; Tang, Ying; Huang, Xiao R; Ming-Kuen Tang, Patrick; Xu, Anping; Szalai, Alexander J; Lou, Tan-Qi; Lan, Hui Y

Lai, Weiyan; Tang, Ying; Huang, Xiao R; Ming-Kuen Tang, Patrick; Xu, Anping; Szalai, Alexander J; Lou, Tan-Qi; Lan, Hui Y.

Afiliação

Lai W; Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Tang Y; Department of Nephrology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China.
Huang XR; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Ming-Kuen Tang P; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Xu A; Department of Nephrology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China.
Szalai AJ; Department of Medicine, The University of Alabama Birmingham, Birmingham, Alabama 35294, USA.
Lou TQ; Department of Nephrology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Lan HY; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: hylan@cuhk.edu.hk.

Kidney Int ; 90(3): 610-26, 2016 09.

Article em En | MEDLINE | ID: mdl-27470679

Assuntos

Injúria Renal Aguda/patologia; Proteína C-Reativa/metabolismo; Ciclina E/metabolismo; Quinase 2 Dependente de Ciclina/metabolismo; Túbulos Renais/fisiologia; Proteína Smad3/metabolismo; Injúria Renal Aguda/sangue; Animais; Proteína C-Reativa/genética; Linhagem Celular Tumoral; Proliferação de Células; Creatinina/sangue; Ciclina E/genética; Inibidor de Quinase Dependente de Ciclina p27/metabolismo; Modelos Animais de Doenças; Células Epiteliais/metabolismo; Células Epiteliais/fisiologia; Pontos de Checagem da Fase G1 do Ciclo Celular; Humanos; Isoquinolinas/farmacologia; Túbulos Renais/citologia; Sistema de Sinalização das MAP Quinases; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Necrose; Fosforilação; Piridinas/farmacologia; Pirróis/farmacologia; Ratos; Receptores de IgG/metabolismo; Regeneração; Proteína Smad3/antagonistas & inibidores; Proteína Smad3/genética; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

C-reactive protein; Smad3; acute kidney injury; cell cycle arrest; p27

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Ciclina E / Quinase 2 Dependente de Ciclina / Proteína Smad3 / Injúria Renal Aguda / Túbulos Renais Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google