Distribution and factors associated with salivary secretory leukocyte protease inhibitor concentrations.
Oral Dis
; 22(8): 781-790, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27470907
ABSTRACT
OBJECTIVES:
This cross-sectional study examined the distribution and correlates of salivary secretory leukocyte protease inhibitor (SLPI) concentrations within a multinational cohort of men.METHODS:
Extracellular SLPI was measured in oral gargle cell supernatants of 378 men from three countries using an ELISA-based assay. Risk factor data were collected by a questionnaire. Factors associated with SLPI were assessed using linear and logistic regression for continuous and categorical SLPI, respectively.RESULTS:
Among men aged 18-73 years, the median SLPI concentration was 492.0 ng ml-1 (range 2.3-1919.9). In multivariable modeling, men in Brazil and younger men (18-30 years) were more likely to have higher levels of SLPI [adjusted odds ratio (aOR) 3.84; 95% confidence interval (CI) 1.94-7.59, and aOR 3.84; 95% CI 1.98-7.43, respectively]. Men with a self-reported sexually transmitted diseases diagnosis in the past 6 months were more likely to have higher SLPI levels (aOR 2.98; 95% CI 1.1-7.83) and men reporting bleeding/swollen gums were less likely to have higher SLPI (aOR 0.34; 95% CI 0.15-0.79). Similar results were observed for linear regression models.CONCLUSIONS:
Secretory leukocyte protease inhibitor concentrations varied significantly by country and decreased with increasing age. The interaction between SLPI, modifiable factors, and oral infections that influence cancer risk warrants further investigation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Inibidor Secretado de Peptidases Leucocitárias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article