Improvement of daptomycin production via increased resistance to decanoic acid in Streptomyces roseosporus.

Lee, Sung-Kwon; Kim, Hong Rip; Jin, Ying-Yu; Yang, Seung Hwan; Suh, Joo-Won

Lee, Sung-Kwon; Kim, Hong Rip; Jin, Ying-Yu; Yang, Seung Hwan; Suh, Joo-Won.

Afiliação

Lee SK; Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 449728, South Korea.
Kim HR; Interdisciplinary Program of Biomodulation, Myongji University, Yongin 449728, South Korea.
Jin YY; Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 449728, South Korea.
Yang SH; Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 449728, South Korea; Interdisciplinary Program of Biomodulation, Myongji University, Yongin 449728, South Korea.
Suh JW; Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin 449728, South Korea. Electronic address: jwsuh@mju.ac.kr.

J Biosci Bioeng ; 122(4): 427-33, 2016 Oct.

Article em En | MEDLINE | ID: mdl-27478150

Assuntos

Antibacterianos/biossíntese; Daptomicina/biossíntese; Ácidos Decanoicos/metabolismo; Ácidos Decanoicos/farmacologia; Farmacorresistência Bacteriana/efeitos dos fármacos; Streptomyces/efeitos dos fármacos; Streptomyces/metabolismo; Reatores Biológicos; Farmacorresistência Bacteriana/genética; Fermentação/efeitos dos fármacos; Streptomyces/genética; Streptomyces/crescimento & desenvolvimento; Triptofano/metabolismo

Palavras-chave

Daptomycin; Decanoic acid; Sequential adaptation; Streptomyces roseosporus; Toxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptomyces / Daptomicina / Farmacorresistência Bacteriana / Ácidos Decanoicos / Antibacterianos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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