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6-Aryl substituted 4-(4-cyanomethyl) phenylamino quinazolines as a new class of isoform-selective PI3K-alpha inhibitors.
Yadav, Rammohan R; Guru, Santosh K; Joshi, Prashant; Mahajan, Girish; Mintoo, Mubashir J; Kumar, Vikas; Bharate, Sonali S; Mondhe, Dilip M; Vishwakarma, Ram A; Bhushan, Shashi; Bharate, Sandip B.
Afiliação
  • Yadav RR; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Guru SK; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Joshi P; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Mahajan G; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Mintoo MJ; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Kumar V; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Preformulation Laboratory, PKPD Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Bharate SS; Preformulation Laboratory, PKPD Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Mondhe DM; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Vishwakarma RA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
  • Bhushan S; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address: sbhushan@iiim.ac.in.
  • Bharate SB; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address: sbharate@iiim.ac.in.
Eur J Med Chem ; 122: 731-743, 2016 Oct 21.
Article em En | MEDLINE | ID: mdl-27479483
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Inibidores Enzimáticos / Inibidores de Fosfoinositídeo-3 Quinase Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Inibidores Enzimáticos / Inibidores de Fosfoinositídeo-3 Quinase Idioma: En Ano de publicação: 2016 Tipo de documento: Article