Insights into the structure and function of HV1 from a meta-analysis of mutation studies.
J Gen Physiol
; 148(2): 97-118, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27481712
ABSTRACT
The voltage-gated proton channel (HV1) is a widely distributed, proton-specific ion channel with unique properties. Since 2006, when genes for HV1 were identified, a vast array of mutations have been generated and characterized. Accessing this potentially useful resource is hindered, however, by the sheer number of mutations and interspecies differences in amino acid numbering. This review organizes all existing information in a logical manner to allow swift identification of studies that have characterized any particular mutation. Although much can be gained from this meta-analysis, important questions about the inner workings of HV1 await future revelation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ativação do Canal Iônico
/
Canais Iônicos
/
Mutação
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article