Angiopep2-functionalized polymersomes for targeted doxorubicin delivery to glioblastoma cells.

Figueiredo, Patrícia; Balasubramanian, Vimalkumar; Shahbazi, Mohammad-Ali; Correia, Alexandra; Wu, Dalin; Palivan, Cornelia G; Hirvonen, Jouni T; Santos, Hélder A

Figueiredo, Patrícia; Balasubramanian, Vimalkumar; Shahbazi, Mohammad-Ali; Correia, Alexandra; Wu, Dalin; Palivan, Cornelia G; Hirvonen, Jouni T; Santos, Hélder A.

Afiliação

Figueiredo P; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Balasubramanian V; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: vimalkumar.balasubramanian@helsinki.fi.
Shahbazi MA; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Correia A; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Wu D; Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
Palivan CG; Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland.
Hirvonen JT; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Santos HA; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address: helder.santos@helsinki.fi.

Int J Pharm ; 511(2): 794-803, 2016 Sep 25.

Article em En | MEDLINE | ID: mdl-27484836

Assuntos

Doxorrubicina/farmacologia; Doxorrubicina/farmacocinética; Portadores de Fármacos/química; Portadores de Fármacos/farmacocinética; Peptídeos/química; Linhagem Celular Tumoral/metabolismo; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Dimetilpolisiloxanos/química; Doxorrubicina/química; Liberação Controlada de Fármacos; Humanos; Poliaminas/química

Palavras-chave

Angiopep2; Cancer therapy; Drug delivery; Intracellular uptake; Polymersomes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Portadores de Fármacos / Doxorrubicina Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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