Tirucallane-type triterpenoids from the fruits of Phellodendron chinense Schneid and their cytotoxic activities.
Fitoterapia
; 113: 132-8, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27491752
ABSTRACT
Eleven triterpenoids were isolated from the fruits of Phellodendron chinense Schneid, and their structures were determined by spectroscopic analysis. The results show that four new tirucallane-type triterpenoids 1, 2, 5, and 6 and seven known compounds 3, 4, 7, 8, 9, 10, and 11 were isolated. Structurally, compound 6 was uncommon; it has a chlorine atom instead of a methyl group at the C-20 position. The cytotoxicities of the compounds was evaluated against the in vitro proliferation of four human tumor cell lines HEL, K562, MDA, and PC3 using adriamycin as the positive control. Compound 1 showed a similar cytotoxicity as the positive control; compounds 3 and 10 showed moderate cytotoxicities compared to the control (P<0.05). This indicates that these compounds have great potential for the development of new antitumor drugs.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Phellodendron
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Frutas
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article