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Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice.
Vingill, Siv; Brockelt, David; Lancelin, Camille; Tatenhorst, Lars; Dontcheva, Guergana; Preisinger, Christian; Schwedhelm-Domeyer, Nicola; Joseph, Sabitha; Mitkovski, Miso; Goebbels, Sandra; Nave, Klaus-Armin; Schulz, Jörg B; Marquardt, Till; Lingor, Paul; Stegmüller, Judith.
Afiliação
  • Vingill S; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany Neuroscience, International Max Planck Research School, Göttingen, Germany.
  • Brockelt D; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany Neuroscience, International Max Planck Research School, Göttingen, Germany.
  • Lancelin C; European Neuroscience Institute (ENI), Göttingen, Germany.
  • Tatenhorst L; Neurology, University Medical Center, Göttingen, Germany Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CMPB), Göttingen, Germany.
  • Dontcheva G; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany Neuroscience, International Max Planck Research School, Göttingen, Germany Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany.
  • Preisinger C; Proteomics Facility, Interdisciplinary Center for Clinical Research (IZKF) Aachen, Medical Faculty, RWTH Aachen, Aachen, Germany.
  • Schwedhelm-Domeyer N; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Joseph S; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany Neuroscience, International Max Planck Research School, Göttingen, Germany Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany.
  • Mitkovski M; Light Microscopy Facility, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Goebbels S; Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Nave KA; Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CMPB), Göttingen, Germany Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  • Schulz JB; Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany.
  • Marquardt T; European Neuroscience Institute (ENI), Göttingen, Germany Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CMPB), Göttingen, Germany Section Neurobiological Research, Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany.
  • Lingor P; Neurology, University Medical Center, Göttingen, Germany Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CMPB), Göttingen, Germany.
  • Stegmüller J; Cellular and Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CMPB), Göttingen, Germany Department of Neurology, University Hospital, RWTH Aachen, Aachen, Germany jstegmueller@ukaachen.de.
EMBO J ; 35(18): 2008-25, 2016 09 15.
Article em En | MEDLINE | ID: mdl-27497298
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Parkinsonianos / Proteínas F-Box / Complexo de Endopeptidases do Proteassoma / Técnicas de Inativação de Genes Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Parkinsonianos / Proteínas F-Box / Complexo de Endopeptidases do Proteassoma / Técnicas de Inativação de Genes Idioma: En Ano de publicação: 2016 Tipo de documento: Article