Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-ß1-40 in Hippocampal Cells.

Li, Yan; Chang, Lirong; Song, Yizhi; Gao, Xianghong; Roselli, Francesco; Liu, Jinping; Zhou, Wei; Fang, Yuan; Ling, Wei; Li, Hui; Almeida, Osborne F X; Wu, Yan

Li, Yan; Chang, Lirong; Song, Yizhi; Gao, Xianghong; Roselli, Francesco; Liu, Jinping; Zhou, Wei; Fang, Yuan; Ling, Wei; Li, Hui; Almeida, Osborne F X; Wu, Yan.

Afiliação

Li Y; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Chang L; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Song Y; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Gao X; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Roselli F; Departments of Neurology and Anatomy, University of Ulm School of Medicine, Germany.
Liu J; Max Planck Institute of Psychiatry, Munich, Germany.
Zhou W; School of Medicine, Tsinghua University, Beijing, China.
Fang Y; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Ling W; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Li H; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Almeida OF; Department of Anatomy, Ministry of Science and Technology Laboratory of Brain Disorders, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Wu Y; Max Planck Institute of Psychiatry, Munich, Germany.

J Alzheimers Dis ; 54(1): 135-48, 2016 08 01.

Article em En | MEDLINE | ID: mdl-27497478

Assuntos

Peptídeos beta-Amiloides/toxicidade; Astrócitos/metabolismo; Hipocampo/metabolismo; Fragmentos de Peptídeos/toxicidade; Receptores de N-Metil-D-Aspartato/metabolismo; Sinapses/metabolismo; Animais; Astrócitos/efeitos dos fármacos; Astrócitos/patologia; Comunicação Celular/efeitos dos fármacos; Comunicação Celular/fisiologia; Células Cultivadas; Técnicas de Cocultura; Espinhas Dendríticas/efeitos dos fármacos; Espinhas Dendríticas/metabolismo; Espinhas Dendríticas/patologia; Fármacos Atuantes sobre Aminoácidos Excitatórios/farmacologia; Hipocampo/efeitos dos fármacos; Hipocampo/patologia; N-Metilaspartato/metabolismo; N-Metilaspartato/farmacologia; Fator de Crescimento Neural/metabolismo; Neuroproteção/efeitos dos fármacos; Neuroproteção/fisiologia; Ratos Wistar; Receptores de N-Metil-D-Aspartato/agonistas; Receptores de N-Metil-D-Aspartato/antagonistas & inibidores; Sinapses/efeitos dos fármacos; Sinapses/patologia

Palavras-chave

Amyloid-beta; N-methyl-D-aspartate receptors; astrocyte; synaptotoxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Sinapses / Astrócitos / Peptídeos beta-Amiloides / Receptores de N-Metil-D-Aspartato / Hipocampo Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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