Diabetes and increased lipid peroxidation are associated with systemic inflammation even in well-controlled patients.
J Diabetes Complications
; 30(8): 1593-1599, 2016.
Article
em En
| MEDLINE
| ID: mdl-27497685
ABSTRACT
BACKGROUND:
The effect of the interaction between type 2 diabetes and dyslipidemia on inflammation and lipid peroxidation (LPO) has not been assessed.AIM:
To investigate whether diabetes coupled with dyslipidemia alters oxidative metabolism leading to increased LPO products and inflammatory status.METHODS:
100 patients were divided into four groups based upon diabetic and dyslipidemic status poorly controlled diabetes with dyslipidemia (DM-PC/D), well-controlled diabetes with dyslipidemia (DM-WC/D), normoglycemic individuals with dyslipidemia (NG/D), and normoglycemic individuals without dyslipidemia (NG/ND). Plasma was evaluated for an LPO product (MDA), antioxidant levels and inflammatory cytokines.RESULTS:
Diabetics presented significantly higher levels of LPO (p<0.05) and the DM-PC/D had higher levels of proinflammatory cytokines and MDA in the plasma in comparison with normoglycemics (p<0.05). Interestingly IL1-ß, IL-6, and TNF-α in DM-WC/D were not statistically different from those in DM-PC/D. Normoglycemic individuals with dyslipidemia presented significantly increased levels of IL-6 and TNF-α when compared to normoglycemic without dyslipidemia (p<0.05). MDA levels were also positively correlated with the presence of DM complications (r=0.42, p<0.01).CONCLUSIONS:
These findings show that dyslipidemia is associated with an increased inflammatory status, even in well-controlled diabetics and in normoglycemics. Our results suggest that lipid metabolism and peroxidation are important for the development of inflammation, which is elevated in several complications associated with diabetes.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Peroxidação de Lipídeos
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Diabetes Mellitus Tipo 2
/
Dislipidemias
/
Inflamação
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article