Dermal uptake and percutaneous penetration of ten flame retardants in a human skin ex vivo model.
Chemosphere
; 162: 308-14, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27513551
ABSTRACT
The dermal uptake and percutaneous penetration of ten organic flame retardants was measured using an ex vivo human skin model. The studied compounds were DBDPE, BTBPE, TBP-DBPE, EH-TBB, BEH-TEBP, α, ß and γ-HBCDD as well as syn- and anti-DDC-CO. Little or none of the applied flame retardants was recovered in either type of the receptor fluids used (physiological and worst-case). However, significant fractions were recovered in the skin depot, particularly in the upper skin layers. The primary effect of the worst-case receptor fluid was deeper penetration into the skin. The recovered mass was used to calculate lower- and upper-bound permeability coefficients kp. Despite large structural variation between the studied compounds, a clear, significant decreasing trend of kp was observed with increasing log Kow. The results indicate that the dermis may provide a significant barrier for these highly lipophilic compounds. However, based on our results, dermal uptake should be considered in exposure assessments, though it may proceed in a time-lagged manner compared to less hydrophobic compounds.
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Base de dados:
MEDLINE
Assunto principal:
Pele
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Absorção Cutânea
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Retardadores de Chama
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Hidrocarbonetos Bromados
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Modelos Biológicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article