PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.

Luo, Tian; Loira-Pastoriza, Cristina; Patil, Harshad P; Ucakar, Bernard; Muccioli, Giulio G; Bosquillon, Cynthia; Vanbever, Rita

Luo, Tian; Loira-Pastoriza, Cristina; Patil, Harshad P; Ucakar, Bernard; Muccioli, Giulio G; Bosquillon, Cynthia; Vanbever, Rita.

Afiliação

Luo T; Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery & Biomaterials, Brussels, Belgium; University of Nottingham, School of Pharmacy, Nottingham, United Kingdom.
Loira-Pastoriza C; Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery & Biomaterials, Brussels, Belgium.
Patil HP; Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery & Biomaterials, Brussels, Belgium.
Ucakar B; Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery & Biomaterials, Brussels, Belgium.
Muccioli GG; Université catholique de Louvain, Louvain Drug Research Institute, Bioanalysis and Pharmacology of Bioactive Lipids, Brussels, Belgium.
Bosquillon C; University of Nottingham, School of Pharmacy, Nottingham, United Kingdom.
Vanbever R; Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery & Biomaterials, Brussels, Belgium. Electronic address: rita.vanbever@uclouvain.be.

J Control Release ; 239: 62-71, 2016 10 10.

Article em En | MEDLINE | ID: mdl-27515664

Assuntos

Antineoplásicos Fitogênicos/administração & dosagem; Carcinoma Pulmonar de Lewis/tratamento farmacológico; Sistemas de Liberação de Medicamentos/métodos; Paclitaxel/administração & dosagem; Polietilenoglicóis/administração & dosagem; Animais; Antineoplásicos Fitogênicos/química; Carcinoma Pulmonar de Lewis/patologia; Linhagem Celular Tumoral; Portadores de Fármacos/administração & dosagem; Portadores de Fármacos/química; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Paclitaxel/química; Polietilenoglicóis/química

Palavras-chave

Inhaled chemotherapy; Lung cancer; Paclitaxel; Paclitaxel (PubChem CID: 36314); Polyethylene glycol (PubChem CID: 174); Polymer-drug conjugates; Prodrug; Pulmonary delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Sistemas de Liberação de Medicamentos / Paclitaxel / Carcinoma Pulmonar de Lewis / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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