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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Primiano, Michael J; Lefker, Bruce A; Bowman, Michael R; Bree, Andrea G; Hubeau, Cedric; Bonin, Paul D; Mangan, Matthew; Dower, Ken; Monks, Brian G; Cushing, Leah; Wang, Stephen; Guzova, Julia; Jiao, Aiping; Lin, Lih-Ling; Latz, Eicke; Hepworth, David; Hall, J Perry.
Afiliação
  • Primiano MJ; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Lefker BA; Department of Medicinal Chemistry, Pfizer, Cambridge, MA 02139;
  • Bowman MR; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Bree AG; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Hubeau C; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Bonin PD; Primary Pharmacology Group, Pfizer, Groton, CT 06340;
  • Mangan M; Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases, 53175 Bonn, Germany;
  • Dower K; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Monks BG; Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 06105; and.
  • Cushing L; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Wang S; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer, Cambridge MA 02139.
  • Guzova J; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Jiao A; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Lin LL; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139;
  • Latz E; Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases, 53175 Bonn, Germany; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 06105; and.
  • Hepworth D; Department of Medicinal Chemistry, Pfizer, Cambridge, MA 02139;
  • Hall JP; Inflammation & Immunology Research Unit, Pfizer, Cambridge, MA 02139; james.p.hall@pfizer.com.
J Immunol ; 197(6): 2421-33, 2016 09 15.
Article em En | MEDLINE | ID: mdl-27521339
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Sulfonas / Dermatite / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Compostos Heterocíclicos de 4 ou mais Anéis / Inflamação Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia / Sulfonas / Dermatite / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Compostos Heterocíclicos de 4 ou mais Anéis / Inflamação Idioma: En Ano de publicação: 2016 Tipo de documento: Article