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Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer.
Povsic, Thomas J; Lawrence, Monica G; Lincoff, A Michael; Mehran, Roxana; Rusconi, Christopher P; Zelenkofske, Steven L; Huang, Zhen; Sailstad, Jeffrey; Armstrong, Paul W; Steg, P Gabriel; Bode, Christoph; Becker, Richard C; Alexander, John H; Adkinson, N Franklin; Levinson, Arnold I.
Afiliação
  • Povsic TJ; Duke Clinical Research Institute, Duke Medicine, Durham, NC. Electronic address: thomas.povsic@duke.edu.
  • Lawrence MG; University of Virginia, Charlottesville, Va.
  • Lincoff AM; Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Cleveland, Ohio.
  • Mehran R; Mount Sinai School of Medicine, New York, NY.
  • Rusconi CP; Regado Biosciences, Basking Ridge, NJ.
  • Zelenkofske SL; Regado Biosciences, Basking Ridge, NJ.
  • Huang Z; Duke Clinical Research Institute, Duke Medicine, Durham, NC.
  • Sailstad J; Sailstad and Associates, Inc, Durham, NC.
  • Armstrong PW; Canadian VIGOUR Centre, University of Alberta, Edmonton, Alberta, Canada.
  • Steg PG; Université Paris-Diderot, Sorbonne Paris Cité, Paris, France; Assistance Publique-Hôpitaux de Paris, Paris, France; NHLI, Royal Brompton Hospital, Imperial College, London, United Kingdom.
  • Bode C; University of Freiburg, Freiburg, Germany.
  • Becker RC; University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Alexander JH; Duke Clinical Research Institute, Duke Medicine, Durham, NC.
  • Adkinson NF; Johns Hopkins Asthma and Allergy Center, Baltimore, Md.
  • Levinson AI; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
J Allergy Clin Immunol ; 138(6): 1712-1715, 2016 12.
Article em En | MEDLINE | ID: mdl-27522158
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Aptâmeros de Nucleotídeos / Hipersensibilidade Imediata / Anticorpos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Aptâmeros de Nucleotídeos / Hipersensibilidade Imediata / Anticorpos Idioma: En Ano de publicação: 2016 Tipo de documento: Article