5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility.
Int J Cardiol
; 222: 895-900, 2016 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-27526355
ABSTRACT
BACKGROUND:
Ventricular remodeling following myocardial infarction (MI) is closely associated with cyclooxygenase-2 (COX-2) expression. 5-methoxytryptophan (5-MTP) was reported to control COX-2 expression.OBJECTIVES:
To investigeate the association between 5-MTP and post-MI left ventricular remodeling.METHODS:
This prospective study enrolled 26 non-diabetic patients with first-time ST segment elevation myocardial infarction (STEMI), and 58 controls. Levels of 5-MTP, N-terminal of pro-brain natriuretic peptide (NT-proBNP), aminoterminal propeptide of type III procollagen, matrix metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 were measured at day 1, day 3, 3months, 6months, and 1year post-MI. Echocardiography was performed during the acute stage (within 72h) and 3months, 6months, and 1year post-MI.RESULTS:
The STEMI patients had a significantly lower plasma 5-MTP level at day 1 which reached a nadir at 3months post-MI. The level of 5-MTP at day 3 post-MI was significantly correlated with the level of NT-proBNP 1year post-MI, suggesting that the level of plasma 5-MTP in the early phase after MI may predict subsequent cardiac stress and failure. Receiver operating characteristic curve analysis revealed that plasma 5-MTP had the best area under the curve value to predict plasma NT-proBNP 1year post-MI. Further analysis using net reclassification improvement and integrated discrimination improvement models confirmed that plasma 5-MTP at day 3 post-MI significantly improved the predictive power of each of the parameters.CONCLUSION:
In non-diabetic STEMI patients, plasma 5-MTP levels were associated with biomarkers of post-MI left ventricular remodeling and damage.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triptofano
/
Remodelação Ventricular
/
Infarto do Miocárdio com Supradesnível do Segmento ST
/
Insuficiência Cardíaca
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article