ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.
Int J Mol Sci
; 17(8)2016 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-27529215
ABSTRACT
The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34⺠derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.
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Base de dados:
MEDLINE
Assunto principal:
Sialiltransferases
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Neoplasias da Mama
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Barreira Hematoencefálica
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article