[Changes in proportion and function of peripheral CD4(+)LAP(+) regulatory T cells in children with asthma].
Zhongguo Dang Dai Er Ke Za Zhi
; 18(8): 726-30, 2016 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-27530790
ABSTRACT
OBJECTIVE:
To investigate the changes in the proportion and function of peripheral CD4(+)LAP(+)regulatory T cells (CD4(+)LAP(+)Treg cells) in children with asthma, as well as the role of CD4(+)LAP(+)Treg cells in the pathogenesis of asthma.METHODS:
A total of 75 children who were diagnosed with asthma from March 2014 to September 2015 were enrolled as study subjects, and according to their conditions, they were divided into acute-stage asthma group (40 children) and remission-stage asthma group (35 patients). Another 30 children who underwent physical examination were enrolled as the healthy control group. Flow cytometry was used to determine the percentage of peripheral CD4(+)LAP(+)Treg cells, and [(3)H]-thymidine incorporation assay was performed to analyze the immunosuppression of CD4(+)LAP(+)Treg cells in each group.RESULTS:
The acute-stage asthma group showed significant reductions in the proportion of CD4(+)LAP(+)Treg cells compared with the remission-stage asthma group and the healthy control group (2.0%±1.0% vs 4.1%±2.4%/4.6%±3.0%; P<0.05). The acute-stage asthma group also showed a significant reduction in the immunosuppression rate of CD4(+)LAP(+)Treg cells compared with the remission-stage asthma group and the healthy control group (21%±4% vs 55%±9%/62%±11%; P<0.05).CONCLUSIONS:
In children with asthma, the reduction in the number and inhibitory function of peripheral CD4(+)LAP(+)Treg cells may be involved in the pathogenesis of asthma.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Linfócitos T Reguladores
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article