Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis.
Nat Prod Commun
; 11(6): 725-8, 2016 Jun.
Article
em En
| MEDLINE
| ID: mdl-27534102
ABSTRACT
Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3-18). Their structures were elucidated on the basis of detailed spectroscopic, including 1D and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 µM, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 µM, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 µM at 10 µM concentration.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Saponinas
/
Medicamentos de Ervas Chinesas
/
Momordica
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article