Mechanisms of transcription factor acetylation and consequences in hearts.
Biochim Biophys Acta
; 1862(12): 2221-2231, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27543804
ABSTRACT
Acetylation of proteins as a post-translational modification is gaining rapid acceptance as a cellular control mechanism on par with other protein modification mechanisms such as phosphorylation and ubiquitination. Through genetic manipulations and evolving proteomic technologies, identification and consequences of transcription factor acetylation is beginning to emerge. In this review, we summarize the field and discuss newly unfolding mechanisms and consequences of transcription factor acetylation in normal and stressed hearts. This article is part of a Special Issue entitled The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Doenças Cardiovasculares
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Processamento de Proteína Pós-Traducional
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Miocárdio
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article