Effect of Kineret® on ovarian ischemia reperfusion injury in a rat model.
J Obstet Gynaecol Res
; 42(11): 1525-1533, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27557615
ABSTRACT
AIM:
To investigate the effect of Kineret® on ischemia reperfusion (IR) injury in rat ovaries.METHODS:
Rats were divided into four groups ovarian IR (IRG); 50 mg/kg Kineret® + ovarian IR (KIR-50); 100 mg/kg Kineret® + ovarian IR (KIR-100); and sham operation (SOC). KIR-50 (n = 10) and KIR-100 (n = 10) groups received an intraperitoneal injection of Kineret® at doses of 50 and 100 mg/kg, respectively. IRG and SOC (n = 10) rat groups were given distilled water as solvent using the same method. The results were compared between the groups.RESULTS:
In rats in which IR occurred, oxidant parameters, such as malondialdehyde (MDA) and myeloperoxidase (MPO), were increased, the level of proinflammatory interleukin 1 beta (IL-1ß) was elevated and total glutathione (tGSH) as an antioxidant was decreased in the ovarian tissues. Administration of Kineret® at a dose of 100 mg/kg inhibited the increase of MDA, MOP and IL-1ß and a decrease in tGSH caused by IR more significantly than administration of Kineret® at a dose of 50 mg/kg. In addition, 100 mg/kg Kineret® significantly decreased severe hemorrhage, degeneration and inflammatory signs in the follicular cells, caused by IR. Kineret® at 100 mg/kg markedly ameliorated increased apoptosis in ovarian tissue with IR more significantly than 50 mg/kg kineret.CONCLUSION:
Our findings indicate that Kineret® might be useful in clinical practice for the treatment of damage that may occur as a result of ovarian torsion.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Ovário
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Traumatismo por Reperfusão
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Proteína Antagonista do Receptor de Interleucina 1
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Anti-Inflamatórios
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Antioxidantes
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article