Sacral neuromodulation of nociceptive bladder overactivity in cats.
Neurourol Urodyn
; 36(5): 1270-1277, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-27571328
ABSTRACT
AIMS:
To investigate the effects of electrical stimulation of sacral dorsal/ventral roots on irritation-induced bladder overactivity, reveal possible different mechanisms under nociceptive bladder conditions, and establish a large animal model of sacral neuromodulation.METHODS:
Intravesical infusion of 0.5% acetic acid (AA) was used to irritate the bladder and induce bladder overactivity in cats under α-chloralose anesthesia. Electrical stimulation (5, 15, or 30 Hz) was applied to individual S1-S3 dorsal or ventral roots at or below motor threshold intensity. Repeated cystometrograms (CMGs) were performed with/without the stimulation to determine the inhibition of bladder overactivity.RESULTS:
AA irritation induced bladder overactivity and significantly (P < 0.05) reduced the bladder capacity to 62.6 ± 11.7% of control capacity measured during saline CMGs. At threshold intensity for inducing reflex twitching of the anal sphincter or toe, S1/S2 dorsal root stimulation at 5 Hz but not at 15 or 30 Hz inhibited bladder overactivity and significantly (P < 0.05) increased bladder capacity to 187.3 ± 41.6% and 155.5 ± 9.7% respectively, of AA control capacity. Stimulation of S3 dorsal root or S1-S3 ventral roots was not effective. Repeated stimulation of S1-S3 dorsal root did not induced a post-stimulation inhibition.CONCLUSIONS:
This study established a cat model of sacral neuromodualation of nociceptive bladder overactivity. The results revealed that the mechanisms underlying sacral neuromodulation are different for nociceptive and non-nociceptive bladder activity.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sacro
/
Raízes Nervosas Espinhais
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Terapia por Estimulação Elétrica
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Bexiga Urinária Hiperativa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article