Synergistic and Superimposed Effect of Bone Marrow-Derived Mesenchymal Stem Cells Combined with Fasudil in Experimental Autoimmune Encephalomyelitis.

Yu, Jing-Wen; Li, Yan-Hua; Song, Guo-Bin; Yu, Jie-Zhong; Liu, Chun-Yun; Liu, Jian-Chun; Zhang, Hai-Fei; Yang, Wan-Fang; Wang, Qing; Yan, Ya-Ping; Xiao, Bao-Guo; Ma, Cun-Gen

Yu, Jing-Wen; Li, Yan-Hua; Song, Guo-Bin; Yu, Jie-Zhong; Liu, Chun-Yun; Liu, Jian-Chun; Zhang, Hai-Fei; Yang, Wan-Fang; Wang, Qing; Yan, Ya-Ping; Xiao, Bao-Guo; Ma, Cun-Gen.

Afiliação

Yu JW; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Li YH; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Song GB; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Yu JZ; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Liu CY; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Liu JC; "2011" Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, China.
Zhang HF; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China.
Yang WF; "2011" Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, China.
Wang Q; "2011" Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, China.
Yan YP; Neurological Institute, Tianjin Medical University General Hospital of Tianjin Medical University, Tianjin, China.
Xiao BG; Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. bgxiao@shmu.edu.cn.
Ma CG; Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, China. macungen2001@163.com.

J Mol Neurosci ; 60(4): 486-497, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27573128

Assuntos

1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/análogos & derivados; Encefalomielite Autoimune Experimental/terapia; Transplante de Células-Tronco Mesenquimais/métodos; Células-Tronco Mesenquimais/efeitos dos fármacos; Inibidores de Proteínas Quinases/uso terapêutico; 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/administração & dosagem; 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/farmacologia; 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/uso terapêutico; Animais; Células da Medula Óssea/citologia; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Células Cultivadas; Citocinas/genética; Citocinas/metabolismo; Encefalomielite Autoimune Experimental/tratamento farmacológico; Encefalomielite Autoimune Experimental/metabolismo; Feminino; Galactosilceramidas/metabolismo; Fator Neurotrófico Derivado de Linhagem de Célula Glial/genética; Fator Neurotrófico Derivado de Linhagem de Célula Glial/metabolismo; Células-Tronco Mesenquimais/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fator 88 de Diferenciação Mieloide/genética; Fator 88 de Diferenciação Mieloide/metabolismo; Inibidores de Proteínas Quinases/administração & dosagem; Inibidores de Proteínas Quinases/farmacologia; Receptor 4 Toll-Like/genética; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Experimental autoimmune encephalomyelitis; Fasudil; Mesenchymal stem cells; Rho kinase inhibitor

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Base de dados: MEDLINE Assunto principal: 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina / Transplante de Células-Tronco Mesenquimais / Inibidores de Proteínas Quinases / Encefalomielite Autoimune Experimental / Células-Tronco Mesenquimais Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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