Voltage-Gated Sodium Channels: Evolutionary History and Distinctive Sequence Features.
Curr Top Membr
; 78: 261-86, 2016.
Article
em En
| MEDLINE
| ID: mdl-27586287
ABSTRACT
Voltage-gated sodium channels (Nav) are responsible for the rising phase of the action potential. Their role in electrical signal transmission is so relevant that their emergence is believed to be one of the crucial factors enabling development of nervous system. The presence of voltage-gated sodium-selective channels in bacteria (BacNav) has raised questions concerning the evolutionary history of the ones in animals. Here we review some of the milestones in the field of Nav phylogenetic analysis and discuss some of the most important sequence features that distinguish these channels from voltage-gated potassium channels and transient receptor potential channels.
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Base de dados:
MEDLINE
Assunto principal:
Evolução Molecular
/
Canais de Sódio Disparados por Voltagem
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article