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A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.
Galante, Denise; Ruggeri, Francesco Simone; Dietler, Giovanni; Pellistri, Francesca; Gatta, Elena; Corsaro, Alessandro; Florio, Tullio; Perico, Angelo; D'Arrigo, Cristina.
Afiliação
  • Galante D; Institute for Macromolecular Studies, National Research Council, 16149 Genova, Italy; Section of Pharmacology, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genova, Italy.
  • Ruggeri FS; Ecole Polytechnique Federale de Lausanne (EPLF), 1015 Lausanne, Switzerland; Department of Chemistry, University of Cambridge, CB21EW, United Kingdom.
  • Dietler G; Ecole Polytechnique Federale de Lausanne (EPLF), 1015 Lausanne, Switzerland.
  • Pellistri F; Department of Physics, University of Genova, 16100 Genova, Italy.
  • Gatta E; Department of Physics, University of Genova, 16100 Genova, Italy.
  • Corsaro A; Section of Pharmacology, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genova, Italy.
  • Florio T; Section of Pharmacology, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genova, 16132 Genova, Italy.
  • Perico A; Institute for Macromolecular Studies, National Research Council, 16149 Genova, Italy.
  • D'Arrigo C; Institute for Macromolecular Studies, National Research Council, 16149 Genova, Italy. Electronic address: cristina.darrigo@ge.ismac.cnr.it.
Int J Biochem Cell Biol ; 79: 261-270, 2016 10.
Article em En | MEDLINE | ID: mdl-27592450
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Ácido Pirrolidonocarboxílico / Peptídeos beta-Amiloides / Dobramento de Proteína / Agregados Proteicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Ácido Pirrolidonocarboxílico / Peptídeos beta-Amiloides / Dobramento de Proteína / Agregados Proteicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article