Disposition of a long-acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis).
J Vet Pharmacol Ther
; 40(2): 206-209, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27597645
ABSTRACT
The present study aimed to characterize the pharmacokinetic profile of oxytetracycline long-acting formulation (OTC-LA) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 20 and 30 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 504 h. The plasma concentrations of OTC were measured by high-performance liquid chromatography (HPLC). The concentrations of OTC in the plasma were determined up to 264 h and 432 h after i.m. administration at doses of 20 and 30 mg/kg b.w., respectively. The Cmax values of OTC were 12.11 ± 1.87 µg/mL and 12.27 ± 1.92 µg/mL at doses of 20 and 30 mg/kg, respectively. The AUClast values increased in a dose-dependent fashion. The half-life values were 52.00 ± 14.26 h and 66.80 ± 10.91 h at doses of 20 and 30 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK-PD index (T > MIC), i.m. administration of OTC at a dose of 30 mg/kg b.w once per week might be appropriate for the treatment of susceptible bacterial infection in Thai swamp buffaloes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxitetraciclina
/
Búfalos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article