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The efficacy assessments of alkylating drugs induced by nano-Fe3O4/CA for curing breast and hepatic cancer.
He, Kui; Ma, Ying; Yang, Bin; Liang, Caishuang; Chen, Xiaoming; Cai, Changqun.
Afiliação
  • He K; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
  • Ma Y; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China; Avic Aviation Powerplant Research Institute, Zhuzhou, Hunan 412002, China.
  • Yang B; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
  • Liang C; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
  • Chen X; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China.
  • Cai C; Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China. Electronic address: cai_mao3@hotmail.com.
Spectrochim Acta A Mol Biomol Spectrosc ; 173: 82-86, 2017 Feb 15.
Article em En | MEDLINE | ID: mdl-27599192
ABSTRACT
A new method to evaluate the anticancer activity at the molecular level has been developed. In our assay, the interaction between alkylating anticancer drugs-Fe3O4/CA with DNA has been investigated for the Resonance Light Scattering (RLS) signal enhancement. Water-based nano-Fe3O4, as a probe, has the ability of good solubility, biodegradability and low bulk resistivity etc. The experimental results show that, the activity order of three kinds of drugs is Nimustine (ACNU)>Semustine (Me-CCNU)>Chlormethine (HN2), which is satisfied with the results of the cell apoptosis experiment and the IC50 by MTT method. This assay is simple, sensitive and high efficient. And the theoretical basics for the development of new anticancer drugs as well as the assessments of their efficacy to cure breast and hepatic cancer have been provided.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Ensaios de Seleção de Medicamentos Antitumorais / Antineoplásicos Alquilantes / Nanopartículas Metálicas Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Ensaios de Seleção de Medicamentos Antitumorais / Antineoplásicos Alquilantes / Nanopartículas Metálicas Idioma: En Ano de publicação: 2017 Tipo de documento: Article