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Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
Tong, Benjamin Chun-Kit; Lee, Claire Shuk-Kwan; Cheng, Wing-Hei; Lai, Kwok-On; Foskett, J Kevin; Cheung, King-Ho.
Afiliação
  • Tong BC; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
  • Lee CS; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
  • Cheng WH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
  • Lai KO; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China.
  • Foskett JK; Departments of Physiology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Cheung KH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. HKU-Shenzhen Institute of Research and Innovation, Shenzhen, Gu
Sci Signal ; 9(444): ra89, 2016 09 06.
Article em En | MEDLINE | ID: mdl-27601731
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinalização do Cálcio / Secretases da Proteína Precursora do Amiloide / Presenilina-1 / Doença de Alzheimer / Molécula 1 de Interação Estromal / Mutação / Proteínas de Neoplasias Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinalização do Cálcio / Secretases da Proteína Precursora do Amiloide / Presenilina-1 / Doença de Alzheimer / Molécula 1 de Interação Estromal / Mutação / Proteínas de Neoplasias Idioma: En Ano de publicação: 2016 Tipo de documento: Article