Inhibition of nuclear factor-&#954;B signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.

Kawaguchi, Makiko; Yamamoto, Koji; Kanemaru, Ai; Tanaka, Hiroyuki; Umezawa, Kazuo; Fukushima, Tsuyoshi; Kataoka, Hiroaki

Inhibition of nuclear factor-κB signaling suppresses Spint1-deletion-induced tumor susceptibility in the ApcMin/+ model.

Kawaguchi, Makiko; Yamamoto, Koji; Kanemaru, Ai; Tanaka, Hiroyuki; Umezawa, Kazuo; Fukushima, Tsuyoshi; Kataoka, Hiroaki.

Afiliação

Kawaguchi M; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yamamoto K; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kanemaru A; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Tanaka H; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Umezawa K; Department of Molecular Target Medicine Screening, Aichi Medical University School of Medicine, Aichi, Japan.
Fukushima T; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kataoka H; Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Oncotarget ; 7(42): 68614-68622, 2016 Oct 18.

Article em En | MEDLINE | ID: mdl-27612426

Assuntos

Polipose Adenomatosa do Colo/metabolismo; Glicoproteínas de Membrana/metabolismo; NF-kappa B/metabolismo; Neoplasias/metabolismo; Transdução de Sinais; Polipose Adenomatosa do Colo/genética; Animais; Benzamidas/farmacologia; Transformação Celular Neoplásica/efeitos dos fármacos; Transformação Celular Neoplásica/genética; Cicloexanonas/farmacologia; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/metabolismo; Mucosa Intestinal/patologia; Glicoproteínas de Membrana/genética; Camundongos Knockout; Camundongos Transgênicos; NF-kappa B/antagonistas & inibidores; Neoplasias/genética; Proteínas Secretadas Inibidoras de Proteinases

Palavras-chave

DHMEQ; HAI-1; NF-κB; Spint1; colon cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Transdução de Sinais / NF-kappa B / Polipose Adenomatosa do Colo / Neoplasias Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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