Pharmaceutical evaluation of naftopidil enantiomers: Rat functional assays in vitro and estrogen/androgen induced rat benign prostatic hyperplasia model in vivo.

Huang, Jun-Jun; Cai, Yi; Yi, Yan-Zhen; Huang, Min-Yi; Zhu, Liu; He, Fei; Liu, Xia-Wen; Huang, Bi-Yun; Yuan, Mu

Huang, Jun-Jun; Cai, Yi; Yi, Yan-Zhen; Huang, Min-Yi; Zhu, Liu; He, Fei; Liu, Xia-Wen; Huang, Bi-Yun; Yuan, Mu.

Afiliação

Huang JJ; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China. Electronic address: huangjunjun1985@sina.com.
Cai Y; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China.
Yi YZ; Guangdong PeiZheng College, Guangzhou 510830, PR China.
Huang MY; The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, PR China.
Zhu L; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China.
He F; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, South China Agricultural University, Guangzhou 510642, PR China.
Liu XW; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China.
Huang BY; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China.
Yuan M; Center of Pharmaceutical Research and Development, School of Pharmacy, Guangzhou Medical University, Guangzhou 511400, PR China. Electronic address: mryuanmu838@sina.com.

Eur J Pharmacol ; 791: 473-481, 2016 Nov 15.

Article em En | MEDLINE | ID: mdl-27615445

Assuntos

Androgênios/farmacologia; Estrogênios/farmacologia; Naftalenos/química; Naftalenos/farmacologia; Piperazinas/química; Piperazinas/farmacologia; Hiperplasia Prostática/induzido quimicamente; Hiperplasia Prostática/tratamento farmacológico; Actinas/metabolismo; Antagonistas de Receptores Adrenérgicos alfa 1/química; Antagonistas de Receptores Adrenérgicos alfa 1/farmacologia; Antagonistas de Receptores Adrenérgicos alfa 1/uso terapêutico; Animais; Modelos Animais de Doenças; Avaliação Pré-Clínica de Medicamentos; Masculino; Naftalenos/uso terapêutico; Tamanho do Órgão/efeitos dos fármacos; Piperazinas/uso terapêutico; Antígeno Nuclear de Célula em Proliferação/metabolismo; Próstata/efeitos dos fármacos; Próstata/metabolismo; Próstata/patologia; Hiperplasia Prostática/metabolismo; Hiperplasia Prostática/patologia; Ratos; Ratos Sprague-Dawley; Estereoisomerismo

Palavras-chave

Benign prostatic hyperplasia; Estrogen/androgen; Naftopidil enantiomers; α(1) adrenoceptor blocker

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Hiperplasia Prostática / Estrogênios / Androgênios / Naftalenos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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