Prevalence of DSM-5 Mild Neurocognitive Disorder in Dementia-Free Older Adults: Results of the Population-Based LIFE-Adult-Study.
Am J Geriatr Psychiatry
; 25(4): 328-339, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27618647
ABSTRACT
OBJECTIVE:
The DSM-5 introduces mild neurocognitive disorder (miNCD) as a syndrome that recognizes the potential clinical importance of acquired cognitive deficits being too mild to qualify for diagnosis of dementia. We provide new empirical data on miNCD including total, age-, and sex-specific prevalence rates; number and types of neurocognitive domains being impaired; and diagnostic overlap with the well-established mild cognitive impairment (MCI) concept.DESIGN:
Cross-sectional results of an observational cohort study (LIFE-Adult-Study).SETTING:
General population.PARTICIPANTS:
A total of 1,080 dementia-free individuals, aged 60-79 years. MEASUREMENTS We calculated weighted point prevalence rates with confidence intervals (95% CI) for miNCD and analyzed diagnostic overlap between miNCD and MCI by calculating overall percentage agreement and Cohen's kappa coefficient.RESULTS:
Weighted total prevalence of miNCD was 20.3% (95% CI 17.8-23.0). Prevalence was similar in both sexes, but significantly higher in older age. Two-thirds (66.2%) of the individuals with miNCD showed impairment restricted to only one out of six possible neurocognitive domains. Learning and memory was the most frequently (38.3%) impaired domain in all miNCD-cases, followed by social cognition (26.1%). Analysis of diagnostic overlap with MCI yielded an overall agreement of 98.6% and a kappa of 0.959.CONCLUSIONS:
By considering all six predefined neurocognitive domains, our study observed a substantial proportion of dementia-free older adults having miNCD. Provision of information on the underlying etiology/ies may be of prime importance in future studies aiming at evaluating the clinical relevance of the miNCD syndrome.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Manual Diagnóstico e Estatístico de Transtornos Mentais
/
Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article