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A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Amano, Masayuki; Salcedo-Gómez, Pedro Miguel; Zhao, Rui; Yedidi, Ravikiran S; Das, Debananda; Bulut, Haydar; Delino, Nicole S; Sheri, Venkata Reddy; Ghosh, Arun K; Mitsuya, Hiroaki.
Afiliação
  • Amano M; Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
  • Salcedo-Gómez PM; Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
  • Zhao R; Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
  • Yedidi RS; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Das D; Department of Pharmacology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India.
  • Bulut H; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Delino NS; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Sheri VR; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Ghosh AK; Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.
  • Mitsuya H; Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.
Antimicrob Agents Chemother ; 60(12): 7046-7059, 2016 12.
Article em En | MEDLINE | ID: mdl-27620483
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Protease de HIV / HIV-1 / Inibidores da Protease de HIV / Farmacorresistência Viral Múltipla / Etilaminas Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Protease de HIV / HIV-1 / Inibidores da Protease de HIV / Farmacorresistência Viral Múltipla / Etilaminas Idioma: En Ano de publicação: 2016 Tipo de documento: Article