Transglutaminase 2 overexpression induces depressive-like behavior and impaired TrkB signaling in mice.

Pandya, C D; Hoda, N; Crider, A; Peter, D; Kutiyanawalla, A; Kumar, S; Ahmed, A O; Turecki, G; Hernandez, C M; Terry, A V; Pillai, A

Pandya, C D; Hoda, N; Crider, A; Peter, D; Kutiyanawalla, A; Kumar, S; Ahmed, A O; Turecki, G; Hernandez, C M; Terry, A V; Pillai, A.

Afiliação

Pandya CD; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Hoda N; Department of Medical Laboratory, Imaging and Radiologic Sciences, Augusta University, Augusta, GA, USA.
Crider A; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Peter D; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Kutiyanawalla A; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Kumar S; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Ahmed AO; Department of Psychiatry, Weill Cornell Medical College, White Plains, NY, USA.
Turecki G; McGill Group for Suicide Studies, Depressive Disorders Program, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.
Hernandez CM; Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Terry AV; Department of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Pillai A; Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Mol Psychiatry ; 22(5): 745-753, 2017 05.

Article em En | MEDLINE | ID: mdl-27620841

Assuntos

Depressão/enzimologia; Proteínas de Ligação ao GTP/biossíntese; Receptor trkB/metabolismo; Transglutaminases/biossíntese; Animais; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Depressão/metabolismo; Feminino; Proteínas de Ligação ao GTP/genética; Humanos; Masculino; Glicoproteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Neurônios/metabolismo; Córtex Pré-Frontal/metabolismo; Gravidez; Proteína 2 Glutamina gama-Glutamiltransferase; RNA Mensageiro/metabolismo; Serotonina/metabolismo; Transdução de Sinais; Suicídio; Transglutaminases/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transglutaminases / Proteínas de Ligação ao GTP / Receptor trkB / Depressão Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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