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Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.
Tong, Ling; Yu, Wensheng; Coburn, Craig A; Meinke, Peter T; Nair, Anilkumar G; Dwyer, Michael P; Chen, Lei; Selyutin, Oleg; Rosenblum, Stuart B; Jiang, Yueheng; Fells, James; Hu, Bin; Zhong, Bin; Soll, Richard M; Liu, Rong; Agrawal, Sony; Xia, Ellen; Zhai, Ying; Kong, Rong; Ingravallo, Paul; Nomeir, Amin; Asante-Appiah, Ernest; Kozlowski, Joseph A.
Afiliação
  • Tong L; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Yu W; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Coburn CA; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Meinke PT; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Nair AG; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Dwyer MP; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Chen L; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Selyutin O; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Rosenblum SB; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Jiang Y; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Fells J; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Hu B; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China.
  • Zhong B; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China.
  • Soll RM; Department of Medicinal Chemistry, WuXi AppTec, Shanghai 200131, China.
  • Liu R; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Agrawal S; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Xia E; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Zhai Y; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Kong R; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Ingravallo P; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Nomeir A; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Asante-Appiah E; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
  • Kozlowski JA; Merck Research Laboratories, 126 E. Lincoln Ave., Rahway, NJ 07065, USA.
Bioorg Med Chem Lett ; 26(20): 5132-5137, 2016 10 15.
Article em En | MEDLINE | ID: mdl-27634194
ABSTRACT
Herein, we describe our research efforts to develop unique cores in molecules which function as HCV nonstructural protein 5A (NS5A) inhibitors. In particular, various fused tetracyclic cores were identified which showed genotype and mutant activities comparable to the indole-based tetracyclic core.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas não Estruturais Virais / Indóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas não Estruturais Virais / Indóis Idioma: En Ano de publicação: 2016 Tipo de documento: Article